(SEM-II) THEORY EXAMINATION 2019-20 HUMAN ANATOMY AND PATHOPHYSIOLOGY-II

B.Pharm (Sem II) – Human Anatomy and Physiology II

Detailed Explanation of Questions and Answers

Human Anatomy and Physiology studies the structure and functions of the human body. Anatomy deals with the physical organization of organs and tissues, while physiology explains how these structures perform various biological processes necessary for life. This knowledge is essential for pharmacy students because many drugs act on specific organs, tissues, and physiological systems. 

Section A – Detailed Answers

Action Potential

An action potential is a rapid electrical impulse that travels along the membrane of a nerve cell or neuron. It occurs when the membrane potential of the neuron changes due to the movement of ions across the cell membrane.

During an action potential, sodium ions rapidly enter the neuron, causing depolarization. This is followed by the exit of potassium ions, which restores the membrane to its resting state.

Action potentials are essential for transmitting signals throughout the nervous system.

Lobes of Cerebral Hemisphere

The cerebrum is divided into four major lobes in each hemisphere. These include the frontal lobe, parietal lobe, temporal lobe, and occipital lobe.

The frontal lobe is responsible for voluntary movement, reasoning, and decision-making. The parietal lobe processes sensory information such as touch and temperature.

The temporal lobe is involved in hearing and memory, while the occipital lobe processes visual information.

Role of Mouth in Digestion

The mouth is the first organ of the digestive system and plays a crucial role in mechanical and chemical digestion.

Mechanical digestion occurs through chewing, which breaks food into smaller pieces. Saliva produced by salivary glands contains enzymes such as amylase that begin the digestion of carbohydrates.

The tongue helps mix food with saliva and forms a bolus that can be easily swallowed.

Vital Capacity and Total Lung Capacity

Vital capacity refers to the maximum amount of air that can be exhaled after a deep inhalation. It includes tidal volume, inspiratory reserve volume, and expiratory reserve volume.

Total lung capacity represents the total volume of air that the lungs can hold after maximum inhalation. It includes vital capacity plus residual volume.

These measurements are important indicators of lung function.

Glomerular Filtration Rate (GFR)

Glomerular filtration rate is the rate at which blood plasma is filtered through the glomeruli of the kidneys. It reflects how effectively the kidneys remove waste products from the blood.

A normal GFR indicates healthy kidney function, while a decreased GFR may indicate kidney disease.

Disorders of Male Reproductive System

Several disorders can affect the male reproductive system. These include prostate enlargement, prostate cancer, erectile dysfunction, and infertility.

Infections and hormonal imbalances may also lead to reproductive problems.

Asthma and Pneumonia

Asthma is a chronic inflammatory disease of the airways characterized by bronchial constriction and difficulty breathing.

Pneumonia is an infection of the lungs that causes inflammation of the alveoli, often leading to fluid accumulation and impaired gas exchange.

Both conditions affect respiratory function but have different causes and mechanisms.

Functions of Hormones

Hormones are chemical messengers produced by endocrine glands and released into the bloodstream.

They regulate various physiological processes such as metabolism, growth, reproduction, and fluid balance.

Hormones help coordinate the activities of different organs and maintain homeostasis in the body.

Cushing Syndrome

Cushing syndrome is a disorder caused by prolonged exposure to high levels of cortisol in the body.

This condition may occur due to excessive production of cortisol by the adrenal glands or prolonged use of corticosteroid medications.

Symptoms include weight gain, high blood pressure, muscle weakness, and changes in skin appearance.

Fertilization in Females

Fertilization usually occurs in the fallopian tube, specifically in the ampulla region.

During fertilization, a sperm cell penetrates the ovum, resulting in the formation of a zygote. This marks the beginning of embryonic development.

Section B – Detailed Explanation

Cerebrospinal Fluid and Its Circulation

Cerebrospinal fluid (CSF) is a clear fluid that surrounds the brain and spinal cord. It is produced by the choroid plexus located in the ventricles of the brain.

CSF protects the brain by acting as a cushion against mechanical injury. It also helps maintain chemical stability and removes metabolic waste products.

The fluid circulates through the ventricles, around the brain and spinal cord, and is eventually absorbed into the bloodstream.

Medulla Oblongata

The medulla oblongata is a part of the brainstem that connects the brain to the spinal cord.

It controls several vital functions such as heart rate, breathing, blood pressure, and reflex actions including swallowing and coughing.

Damage to the medulla oblongata can be life-threatening because it regulates essential physiological processes.

Female Reproductive Cycle

The female reproductive cycle consists of several phases that prepare the body for pregnancy.

The cycle begins with the menstrual phase, during which the uterine lining is shed. This is followed by the follicular phase, during which follicles in the ovary begin to mature.

Ovulation occurs around the middle of the cycle when an ovum is released from the ovary.

The luteal phase follows ovulation and prepares the uterus for possible implantation of a fertilized egg.

Mechanism of ATP Formation

ATP formation occurs mainly through cellular respiration in mitochondria.

During glycolysis, glucose is broken down into pyruvate. The citric acid cycle further oxidizes these molecules to produce electron carriers such as NADH.

These carriers transfer electrons to the electron transport chain, where energy is used to produce ATP through oxidative phosphorylation.

Section C – Detailed Explanation

Signal Transmission at Chemical Synapse

A chemical synapse is the junction between two neurons where communication occurs through neurotransmitters.

When an action potential reaches the presynaptic terminal, neurotransmitters are released into the synaptic cleft. These molecules bind to receptors on the postsynaptic membrane and generate a new electrical signal.

This process allows neurons to communicate and coordinate body functions.

Hormones of Pancreas

The pancreas contains endocrine cells that produce important hormones.

Insulin lowers blood glucose levels by promoting uptake of glucose into cells. Glucagon increases blood glucose by stimulating breakdown of glycogen in the liver.

These hormones maintain blood sugar balance in the body.

Nephron

The nephron is the functional unit of the kidney responsible for urine formation.

It consists of the glomerulus and renal tubules. Filtration occurs in the glomerulus, while reabsorption and secretion occur in the tubules.

These processes help maintain fluid and electrolyte balance in the body.

Basal Metabolic Rate (BMR)

Basal metabolic rate is the minimum amount of energy required to maintain essential physiological functions while the body is at rest.

It includes energy required for breathing, circulation, and maintenance of body temperature.

Factors affecting BMR include age, sex, body size, hormonal activity, and environmental temperature.

Gland of Emergency

The adrenal gland is often called the “gland of emergency.”

This is because it produces hormones such as adrenaline that prepare the body to respond to stressful situations.

These hormones increase heart rate, blood pressure, and energy availability during emergencies.

Genetics and Chromosomes

Genetics is the study of heredity and how traits are transmitted from parents to offspring.

Chromosomes are thread-like structures located in the nucleus of cells that contain DNA and genetic information.

Humans normally have 46 chromosomes arranged in 23 pairs.

Conclusion

Human Anatomy and Physiology provides a detailed understanding of how the body functions and maintains internal balance. For pharmacy students, this knowledge is essential because drugs interact with various organs and physiological systems.

Understanding normal body functions also helps in recognizing disease mechanisms and designing effective treatments.